The boy's and girl's name Santana \s(a)-nta-na, san-tana\ is of Spanish origin, and its meaning is "holy". Name of a rock band famous in the 60s and 70s.
Santana has 1 variant form: Santa.
Santana is a common female first name and a very popular surname (source: 1990 U.S. Census). Displayed below is the baby name popularity trend for the girl's name Santana. Click here to compare Santana with related baby names.
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