Meaning and name origin
Sissie \s(is)-sie\ as a girl's name is of Latin and Old Welsh origin, and the meaning of Sissie is "blind; sixth". Sissie is a variant of Cecilia (Latin, Old Welsh): the name came from the Welsh name Seissylt meaning "sixth". Also a variant of Cicely (Latin, Old Welsh): the English variant of Cecily and Cecilia. Sissie is also used as a variant of Sissy.
Sissie is not a popular first name for females and an equally uncommon surname or last name for all people (2000 U.S. Census).
Displayed below is a comparison of the popularity of the girl name Sissie and its variant forms. The only popular variation form ranked in the Top 1000/100 is Cecilia (#206). (2014 statistics).