Meaning and name origin
Isa \i-sa\ as a boy's name (also used as girl's name Isa), is of Hebrew origin, and the meaning of Isa is "laughter; God is salvation". Isa is a variant of Isaac (Hebrew); biblical: the only son of Abraham by his wife Sarah. Also a variant of Isaiah (Hebrew); biblical: one of the major prophets and writer of the Book of Isaiah.
Isa is not a popular first name for males but a very popular surname or last name for all people (#25494 out of 88799, Top 29%) (2000 U.S. Census).
Displayed below is a comparison of the popularity of the boy name Isa and its variant forms. Popular variation forms ranked in the Top 1000/100 are Isaac (#31), Isaiah (#48), Izaiah (#459) and Isiah. (2014 statistics).