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The boy's name Santo \s(a)-nto, san-to\ is of Italian and Spanish origin, and its meaning is "holy". From the Latin word "sanctus". Santo has 1 variant form: Sante. For more information, see also the related name Santos. Baby names that sound like Santo are Sandy, Saint and Santee. Santo is an uncommon male first name and a very popular surname (source: 1990 U.S. Census). Displayed below is the baby name popularity trend for the boy's name Santo. Click here to compare Santo with related baby names.
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